Description

5-(1,3-Dioxolan-2-Yl)-2-Thienylzinc Bromide is a highly reactive organozinc reagent, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as Negishi coupling, to construct complex heterocyclic and functionalized molecular architectures with high selectivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 5-(1,3-dioxolan-2-yl)-2-thienyl moiety into target molecules during the research and development of new active pharmaceutical ingredients (APIs).
• Negishi Cross-Coupling Reactions: Used as a robust organozinc partner for palladium-catalyzed cross-coupling with various aryl, heteroaryl, and vinyl halides, enabling carbon-carbon bond formation.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that incorporate thiophene-based structures for enhanced biological activity.
• Material Science & Organic Electronics: Serves as a precursor for constructing π-conjugated systems and functionalized thiophene derivatives used in organic light-emitting diodes (OLEDs) and semiconductors.
• Ligand & Catalyst Development: Useful for preparing specialized ligands and metal-organic complexes for catalytic applications.
• Academic & Process R&D: A valuable tool for methodological development and scaling up synthetic routes in laboratory and pilot plant settings.

Basic Information

Product Name	5-(1,3-Dioxolan-2-Yl)-2-Thienylzinc Bromide
CAS No.	307531-84-6
Molecular Formula	C9H9BrO2SZn
Molecular Weight	326.52 g/mol
Synonyms	2-(1,3-Dioxolan-2-yl)thiophene-5-zinc bromide; 5-(1,3-Dioxolan-2-yl)thiophen-2-ylzinc bromide; 2-Thienylzinc bromide, 5-(1,3-dioxolan-2-yl)-; (5-(1,3-Dioxolan-2-yl)thiophen-2-yl)zinc bromide; Zinc, bromo[5-(1,3-dioxolan-2-yl)-2-thienyl]-; 5-(2-Thienyl)-1,3-dioxolane-2-zinc bromide (rearranged); Thiophene-2-zinc bromide, 5-(1,3-dioxolan-2-yl) derivative
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxolan-2-Yl)-2-Thienylzinc Bromide is manufactured and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (by titration), residual solvent content, and concentration in solution. Our quality systems are designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Keep the container tightly sealed in a dry, inert gas-filled glovebox or desiccator when not in use.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (Typical, custom concentrations available)
Purity (HPLC)	≥ 95% (Organozinc species)
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.