Description

3,4-Difluorobenzylzinc Bromide is a highly reactive organozinc reagent, specifically a benzylzinc halide, used as a key building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, to introduce the valuable 3,4-difluorobenzyl moiety into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and scalable methods for fluorinated compound synthesis.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs) containing difluorobenzyl groups, which are common in drug discovery for optimizing potency and metabolic stability.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides where the difluorobenzyl unit can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Employed in the development of fluorinated organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: Primarily utilized in Negishi-type cross-coupling with various electrophiles (e.g., aryl halides, acid chlorides) to form new C-C bonds under mild conditions.
• Process Chemistry & Scale-Up: Provides a reliable and atom-efficient route for the large-scale production of fluorinated fine chemicals and target molecules.

Basic Information

Product Name	3,4-Difluorobenzylzinc Bromide
CAS No.	307496-34-0
Molecular Formula	C7H5BrF2Zn
Molecular Weight	272.42 g/mol
Synonyms	(3,4-Difluorobenzyl)zinc bromide; Zinc, bromo(3,4-difluorophenyl)methyl-; 3,4-Difluorobenzylzinc bromide solution; (3,4-Difluorophenyl)methylzinc bromide; Bromo(3,4-difluorobenzyl)zinc; 1-(Bromozincio)methyl-3,4-difluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluorobenzylzinc Bromide is manufactured and handled under strict inert atmosphere conditions to ensure stability and consistent reactivity. Our products undergo rigorous quality testing, including titration for zinc content and analytical methods to confirm identity and solution concentration. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with cGMP and other relevant quality management frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. This compound is highly volatile, easily oxidized, and reacts vigorously with strong acids and protic solvents; ensure storage areas are cool, dry, and well-ventilated. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (Typical)
Assay (Zinc Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Purity (GC/HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.