Description

2,6-Difluorobenzylzinc Bromide is a highly reactive organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in the synthesis of complex, fluorinated aromatic compounds that are difficult to access via other routes. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable and high-purity building block for cross-coupling reactions.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 2,6-difluorobenzyl moiety into target molecules via Negishi, Kumada, or other transition-metal-catalyzed cross-couplings, crucial for developing active pharmaceutical ingredients (APIs).
• Agrochemical Active Ingredient Development: Used in the construction of novel herbicides, fungicides, and insecticides where the difluorobenzyl group imparts desirable biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Advanced Material Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers where precise control over fluorine substitution is required for tuning electronic and physical properties.
• Custom Chemical and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D and scale-up projects.

Basic Information

Product Name	2,6-Difluorobenzylzinc Bromide
CAS No.	307496-33-9
Molecular Formula	C7H5BrF2Zn
Molecular Weight	272.41 g/mol
Synonyms	Benzene, 1-(bromozinciomethyl)-2,6-difluoro-; (2,6-Difluorobenzyl)zinc bromide; Zinc, bromo(2,6-difluorobenzyl)-; 2,6-Difluorobenzyl zinc bromide; 2,6-Difluorobenzylzinc bromide solution; (2,6-Difluorophenylmethyl)zinc bromide
EINECS	Contact for details

Quality Control

Our 2,6-Difluorobenzylzinc Bromide is manufactured under stringent quality systems to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis, including titration for active zinc content, NMR for structural confirmation, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, concentration (typically supplied as a solution in THF or other solvents), and stability data.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). For optimal stability, store the sealed reagent bottle under an inert gas (argon or nitrogen) atmosphere at 2-8°C. Once opened, use promptly and re-purge the container with inert gas before resealing. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98% (relative area)
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.