Description

2,5-Difluorobenzylzinc Bromide is a highly reactive organozinc reagent, specifically a benzylzinc halide derivative. This compound is a critical building block in modern synthetic organic chemistry, enabling the efficient introduction of the 2,5-difluorobenzyl group into complex molecular frameworks. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional molecules. Its utility stems from its ability to participate in cross-coupling reactions, offering a pathway to valuable fluorinated intermediates.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides, herbicides, and fungicides where the difluorobenzyl moiety enhances biological activity and metabolic stability.
• Cross-Coupling Reactions: Essential precursor for Negishi, Kumada, and related transition-metal catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand & Material Science: Building block for the development of specialized ligands for catalysis and fluorinated monomers for advanced polymers with unique properties.
• Chemical Research & Development: A versatile tool for medicinal and process chemistry for exploring new chemical space and optimizing synthetic routes.
• Fluorine Chemistry: Serves as a reliable source of a functionalized benzyl anion equivalent for introducing fluorine atoms at specific positions on an aromatic ring system.

Basic Information

Product Name	2,5-Difluorobenzylzinc Bromide
CAS No.	307496-32-8
Molecular Formula	C7H5BrF2Zn
Molecular Weight	272.42 g/mol
Synonyms	Benzene, 1-(bromozinciomethyl)-2,5-difluoro-; (2,5-Difluorobenzyl)zinc bromide; Zinc, bromo(2,5-difluorobenzyl)-; 2,5-Difluorobenzyl zinc bromide; 2,5-Difluorobenzylzinc bromide solution; (2,5-Difluorophenylmethyl)zinc bromide
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzylzinc Bromide is manufactured under stringent quality protocols. Each batch is analyzed to ensure high purity and consistency, with typical specifications focusing on zinc content, halide content, and solution concentration. We provide comprehensive Certificates of Analysis (COA) detailing all relevant parameters, including assay by titration and identity confirmation. Our quality system is designed to meet the rigorous demands of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended cold temperatures (e.g., 2-8°C or as specified on the label) to maintain stability and prevent decomposition. The material is highly volatile, easily oxidized, and reacts vigorously with strong acids and oxidizing agents. Keep away from heat, sparks, and open flame. Use appropriate ventilation and personal protective equipment when handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in Tetrahydrofuran (Typical)
Assay (Zinc Titration)	≥ 95%
Identification (NMR/IR)	Conforms to structure
Purity (HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.