Description

n-[(Z)-(2-Bromophenyl)Methylidene]-4-(4-Methylphenyl)Piperazin-1-Amine is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel bioactive molecules targeting specific receptors. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and selectivity.
• Chemical Biology Probes: Serves as a precursor for developing labeled compounds or probes to study biological pathways and target engagement.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a specific piperazine-based moiety with a brominated aromatic system.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	n-[(Z)-(2-Bromophenyl)Methylidene]-4-(4-Methylphenyl)Piperazin-1-Amine
CAS No.	307348-57-8
Molecular Formula	C18H18BrN3
Molecular Weight	356.26 g/mol
Synonyms	1-[(Z)-[(2-Bromophenyl)methylene]amino]-4-(4-methylphenyl)piperazine; (Z)-N-[(2-Bromophenyl)methylene]-4-(p-tolyl)piperazin-1-amine; 4-(4-Methylphenyl)-1-[[(2-bromophenyl)methylene]amino]piperazine; 307348-57-8; (Z)-2-Bromo-N-((4-(p-tolyl)piperazin-1-yl)methylene)aniline
EINECS	Contact for details

Quality Control

Our n-[(Z)-(2-Bromophenyl)Methylidene]-4-(4-Methylphenyl)Piperazin-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.