Description

4-([4-(Trifluoromethyl)Anilino]Methyl)-1(2H)-Phthalazinone is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, especially those targeting kinase inhibition and other enzyme-related pathways.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the biological activity of the phthalazinone core.
• Chemical Biology Probe: Employed in academic and industrial research as a tool compound to study biological mechanisms and protein interactions.
• Material Science: Investigated for the development of specialty polymers and advanced organic materials with specific electronic or photophysical properties.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and scale-up projects under GMP or non-GMP conditions.

Basic Information

Product Name	4-([4-(Trifluoromethyl)Anilino]Methyl)-1(2H)-Phthalazinone
CAS No.	305368-12-1
Molecular Formula	C16H12F3N3O
Molecular Weight	319.28 g/mol
Synonyms	4-[(4-Trifluoromethylphenylamino)methyl]-1(2H)-phthalazinone; 4-[(4-Trifluoromethyl-anilino)methyl]-1(2H)-phthalazinone; 4-({[4-(Trifluoromethyl)phenyl]amino}methyl)-1,2-dihydrophthalazin-1-one; 1(2H)-Phthalazinone, 4-[[[4-(trifluoromethyl)phenyl]amino]methyl]-; 4-((4-(Trifluoromethyl)phenylamino)methyl)phthalazin-1(2H)-one
EINECS	Contact for details

Quality Control

Our production of 4-([4-(Trifluoromethyl)Anilino]Methyl)-1(2H)-Phthalazinone adheres to stringent in-process and final release controls to ensure batch-to-batch consistency and high purity. Quality is verified through advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects with specifications tailored to meet GMP, ICH Q7, and other relevant regulatory guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.