Description

4-[(2,4-Difluoroanilino)Methyl]-1(2H)-Phthalazinone is a high-purity, advanced pharmaceutical intermediate characterized by its specific heterocyclic structure. This compound is of significant commercial value for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is primarily sought by pharmaceutical R&D teams, fine chemical manufacturers, and contract research organizations (CROs) engaged in developing new drug candidates.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block in the multi-step synthesis of novel drug molecules, particularly in oncology and central nervous system (CNS) therapeutic research.
• Research & Development (R&D): Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Preclinical and Clinical Trial Material Production: Supplied for the scale-up synthesis of candidate drugs required for non-clinical and clinical studies under GMP-like conditions.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Fine Chemical and Custom Synthesis: Employed by specialty chemical companies for custom manufacturing and the production of tailored molecular entities for clients.

Basic Information

Product Name	4-[(2,4-Difluoroanilino)Methyl]-1(2H)-Phthalazinone
CAS No.	305368-09-6
Molecular Formula	C15H11F2N3O
Molecular Weight	287.26 g/mol
Synonyms	4-[(2,4-Difluorophenylamino)methyl]phthalazin-1(2H)-one; 1(2H)-Phthalazinone, 4-[(2,4-difluoroanilino)methyl]-; 4-[(2,4-Difluoroanilino)methyl]-1,2-dihydrophthalazin-1-one; 4-((2,4-Difluoroanilino)methyl)phthalazin-1(2H)-one; 305368-09-6; 4-(2,4-Difluoroanilinomethyl)-1(2H)-phthalazinone
EINECS	Contact for details

Quality Control

Our 4-[(2,4-Difluoroanilino)Methyl]-1(2H)-Phthalazinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support pharmaceutical-grade requirements and can provide material suitable for research and development under quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.