Description

(2S,αr)-α-(Aminomethyl)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Methanol is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its value lies in its unique benzopyran scaffold with fluorine and aminomethyl substituents, which are critical for modulating the biological activity and pharmacokinetic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical industry, particularly those working on central nervous system (CNS) agents, cardiovascular drugs, and other therapeutic areas requiring sophisticated chiral synthons.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and cardiovascular applications.
• Chiral Building Block: Used in asymmetric synthesis to construct complex molecules with defined stereochemistry for drug discovery programs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities, leveraging the fluorine atom for metabolic stability and the aminomethyl group for derivatization.
• Process Chemistry Development: Utilized in scaling up synthetic routes for candidate drugs during clinical development phases.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of investigational and commercial drugs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	(2S,αr)-α-(Aminomethyl)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Methanol
CAS No.	303176-42-3
Molecular Formula	C12H16FNO2
Molecular Weight	225.26 g/mol
Synonyms	(2S,ar)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol; 6-Fluoro-2H-1-benzopyran-2-methanol, α-(aminomethyl)-3,4-dihydro-, (2S,αR)-; (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-chromen-2-methanol; (2S,αR)-6-Fluoro-α-(aminomethyl)-3,4-dihydro-2H-1-benzopyran-2-methanol; 303176-42-3; (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-chromen-2-ylmethanol; (2S,αR)-6-Fluoro-α-(aminomethyl)chroman-2-methanol.
EINECS	Contact for details

Quality Control

Our (2S,αr)-α-(Aminomethyl)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.