Description

4-Methylphenylzinc Iodide is an organozinc reagent, specifically an arylzinc halide, widely used as a versatile building block in modern synthetic organic chemistry. Its primary value lies in its ability to participate in cross-coupling reactions, such as Negishi coupling, to form new carbon-carbon bonds with high selectivity and functional group tolerance. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 4-methylphenyl (p-tolyl) group into target molecules via metal-catalyzed cross-coupling reactions.
• Agrochemical Active Ingredient Development: Used in the research and scale-up of novel herbicides, fungicides, and insecticides that require specific aryl motifs.
• Material Science & Organic Electronics: Serves as a precursor for creating conjugated polymers and small molecules used in OLEDs, OFETs, and other electronic devices.
• Negishi Coupling Reactions: Functions as a superior organometallic partner with aryl, vinyl, or alkynyl halides/pseudohalides under palladium or nickel catalysis.
• Catalyst & Ligand Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Fine Chemical & Specialty Chemical Production: Utilized for the custom synthesis of dyes, flavors, fragrances, and other high-value aromatic compounds.

Basic Information

Product Name	4-Methylphenylzinc Iodide
CAS No.	300766-53-4
Molecular Formula	C7H7IZn
Molecular Weight	283.43 g/mol
Synonyms	(4-Methylphenyl)zinc iodide; p-Tolylzinc iodide; Zinc, (4-methylphenyl)iodo-; 4-Methylbenzenezinc iodide; p-Methylphenylzinc iodide; 1-Iodo-4-methylbenzenezinc; Tolylzinc iodide; (p-Tolyl)zinc iodide
EINECS	Contact for details

Quality Control

Our 4-Methylphenylzinc Iodide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including titration for active zinc content and spectroscopic identification. A Certificate of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or ether), and impurity profile is provided with every shipment to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is moisture-sensitive (hygroscopic) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. For solutions, store in flame-proof refrigerators and ensure containers are securely sealed to prevent pressure build-up and solvent loss.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (typically 0.5M in THF)
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95% (as (4-Methylphenyl)ZnI)
Concentration	0.4 - 0.6 M in THF (or as specified)
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.