Description

trans-2-Cyanocyclopropanecarboxylic Acid is a high-value, multifunctional cyclopropane derivative characterized by its strained three-membered ring and reactive nitrile and carboxylic acid functional groups. This unique structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block in synthetic organic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, antiviral agents, and other bioactive molecules.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the cyclopropane moiety.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands and organocatalysts for asymmetric synthesis, enhancing reaction selectivity and yield.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of advanced polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, including ring-opening and functionalization reactions.

Basic Information

Product Name	trans-2-Cyanocyclopropanecarboxylic Acid
CAS No.	39891-82-2
Molecular Formula	C5H5NO2
Molecular Weight	111.10 g/mol
Synonyms	(1R,2S)-2-Cyanocyclopropane-1-carboxylic Acid; (1S,2R)-2-Cyanocyclopropane-1-carboxylic Acid; trans-2-Cyano-1-cyclopropanecarboxylic Acid; 2-Cyanocyclopropanecarboxylic Acid; Cyclopropane-1-carboxylic acid, 2-cyano-, trans-; (1R,2S)-rel-2-Cyanocyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-2-Cyanocyclopropanecarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric/excess (ee/de) specifications as required for advanced synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (Typical)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.