Description

4-(Difluoromethoxy)-2-Methylaniline is a specialized aromatic amine derivative featuring a difluoromethoxy substituent. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block for the synthesis of complex organic molecules. It is primarily required by R&D chemists and process development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides, leveraging the stability imparted by the difluoromethoxy group.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials due to its unique electronic properties.
• Dye and Pigment Manufacturing: Intermediate for producing high-performance, light-fast dyes and pigments for industrial applications.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex biaryl amines.
• Fluorine Chemistry Studies: Valuable compound for research in organofluorine chemistry, exploring the effects of fluorine substitution on biological activity and molecular properties.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Methylaniline
CAS No.	39211-57-9
Molecular Formula	C8H9F2NO
Molecular Weight	173.16 g/mol
Synonyms	2-Methyl-4-(difluoromethoxy)aniline; 4-(Difluoromethoxy)-2-methylbenzenamine; 2-Methyl-4-(difluoromethoxy)benzenamine; 2-Amino-5-(difluoromethoxy)toluene; Benzenamine, 4-(difluoromethoxy)-2-methyl-; 4-Amino-3-methylphenyl difluoromethyl ether; DFMA; 39211-57-9
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Methylaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. This amine derivative is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); handle and store under an inert atmosphere for long-term stability if specified.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.