Description

3-Chloro-4-Difluoromethoxy-Phenylamine is a high-purity aromatic amine derivative featuring chloro and difluoromethoxy substituents, serving as a critical advanced intermediate in fine chemical synthesis. Its unique halogenated structure makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-transport materials and charge-generating compounds in electronic displays and organic light-emitting diodes.
• Polymer & Resin Modifiers: Incorporated as a functional monomer to introduce specific halogenated aromatic units into specialty polymers, improving thermal and chemical resistance.
• Dye & Pigment Manufacturing: Acts as an intermediate for synthesizing complex azo dyes and high-performance pigments requiring specific halogen substitution patterns.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing biaryl and complex amine structures in medicinal chemistry.

Basic Information

Product Name	3-Chloro-4-Difluoromethoxy-Phenylamine
CAS No.	39211-55-7
Molecular Formula	C7H6ClF2NO
Molecular Weight	193.58 g/mol
Synonyms	3-Chloro-4-(difluoromethoxy)aniline; 3-Chloro-4-(difluoromethoxy)benzenamine; 4-Amino-2-chloro-1-(difluoromethoxy)benzene; 2-Chloro-4-(difluoromethoxy)aniline; 3-Chloro-4-difluoromethoxyaniline; 3-Chloro-4-difluoromethoxy-phenylamine; Benzenamine, 3-chloro-4-(difluoromethoxy)-; 39211-55-7
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-4-Difluoromethoxy-Phenylamine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature, the container should be opaque or kept in dark conditions. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.