Description

4-Amino-Tetrahydro-Pyran-4-Carboxylic Acid is a versatile bicyclic amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structural motif, featuring both a carboxylic acid and an amino group on a saturated pyran ring, makes it highly valuable for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, neurological agents, and other bioactive molecules requiring rigid, constrained amino acid analogs.
• Agrochemical Research: Used in the development of novel herbicides and fungicides where its structural rigidity can enhance binding affinity and metabolic stability.
• Peptidomimetics & Drug Design: Incorporated into peptide backbones to induce specific conformational constraints, improve metabolic stability, and enhance bioavailability of peptide-based therapeutics.
• Ligand & Catalyst Development: Serves as a precursor for chelating ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Specialty Polymer Monomer: Potential use in creating novel polyamides or functional polymers with unique thermal and mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	4-Amino-Tetrahydro-Pyran-4-Carboxylic Acid
CAS No.	39124-20-4
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	4-Aminotetrahydropyran-4-carboxylic Acid; 4-Amino-4-carboxytetrahydropyran; 4-Aminooxane-4-carboxylic Acid; 4-Aminotetrahydro-2H-pyran-4-carboxylic Acid; 4-Amino-THP-4-COOH; ATCA; 4-Amino-4-pyrancarboxylic Acid; (4-Aminotetrahydro-2H-pyran-4-yl)methanoic Acid
EINECS	Contact for details

Quality Control

Our 4-Amino-Tetrahydro-Pyran-4-Carboxylic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and cGMP manufacturing. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.