Description

2-Hydroxy-3-Butynoic Acid is a versatile bifunctional organic compound containing both a hydroxyl group and an alkyne moiety, making it a valuable building block in synthetic organic chemistry. Its unique structure allows it to serve as a key intermediate for the synthesis of complex molecules, including pharmaceuticals, agrochemicals, and advanced materials. This product is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical, and specialty chemical industries seeking to introduce chiral centers or functionalized acetylene units into their target compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring propargylic alcohol or α-hydroxy acid functionalities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where its alkyne group enables click chemistry or cycloaddition reactions.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer and Material Science: Acts as a monomer or cross-linking agent for creating specialty polymers with tailored properties, such as biodegradable plastics or conductive materials.
• Chemical Biology & Proteomics: Utilized as a building block for bio-conjugation reagents and probes, leveraging the alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reactions.
• Flavor and Fragrance Industry: Intermediate for the synthesis of certain aroma chemicals and natural product analogs.

Basic Information

Product Name	2-Hydroxy-3-Butynoic Acid
CAS No.	38628-65-8
Molecular Formula	C4H4O3
Molecular Weight	100.07 g/mol
Synonyms	3-Butyn-2-ol-2-carboxylic Acid; 2-Hydroxybut-3-ynoic Acid; 3-Butynoic acid, 2-hydroxy-; Propiolic acid, 2-hydroxy-; Acetylene glycolic acid; 2-Hydroxy-3-butynoate; 2-Hydroxy-3-butynoic acid, 2-Hydroxy-3-butynoic acid (CAS 38628-65-8)
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Butynoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.