Description

4-(Chloromethyl)-1H-Imidazole Hydrochloride is a versatile and reactive heterocyclic building block essential for advanced organic synthesis. Its bifunctional nature, featuring both an imidazole core and a reactive chloromethyl group, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), bioactive molecules, and specialized ligands.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of histamine H3 receptor antagonists, antifungal agents, and other nitrogen-containing heterocyclic drugs.
• Agrochemical Synthesis: Building block for creating novel fungicides, herbicides, and plant growth regulators with imidazole-based activity.
• Ligand and Catalyst Preparation: Used to synthesize N-heterocyclic carbene (NHC) precursors and other specialized ligands for coordination chemistry and catalysis.
• Material Science Research: Intermediate for developing functional polymers, ionic liquids, and advanced organic materials with tailored properties.
• Bioconjugation and Labeling: The reactive chloromethyl group enables its use in modifying biomolecules and creating fluorescent probes or affinity tags.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for use in client-directed research projects and scale-up campaigns.

Basic Information

Product Name	4-(Chloromethyl)-1H-Imidazole Hydrochloride
CAS No.	38585-61-4
Molecular Formula	C4H6Cl2N2
Molecular Weight	153.01 g/mol
Synonyms	1H-Imidazole-4-methanol, 1-(chloromethyl)-, hydrochloride; 4-(Chloromethyl)imidazole hydrochloride; 1-(Chloromethyl)-1H-imidazole-4-methanol hydrochloride; 4-Chloromethylimidazole hydrochloride; (4-Imidazolyl)methyl chloride hydrochloride; 4-Imidazolemethyl chloride hydrochloride; 1H-Imidazole-4-methanol, 1-(chloromethyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Every batch of 4-(Chloromethyl)-1H-Imidazole Hydrochloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive testing, including identity confirmation, purity assay, and impurity profiling, is performed. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and product integrity for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.