Description

2,4,6-Triisopropylbenzyl Chloride is a versatile and highly substituted benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its sterically hindered structure makes it an exceptionally valuable reagent for introducing the bulky 2,4,6-triisopropylbenzyl protecting group, which is crucial for the synthesis of complex pharmaceuticals and specialty chemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key starting material and protecting group reagent in the synthesis of sterically hindered active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where bulky substituents are required for specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized phosphine and N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis and polymerization processes.
• Material Science: Employed in the creation of monomers for high-performance polymers and as a modifying agent for surfaces and dendrimers.
• Organic Synthesis Building Block: A fundamental reagent for alkylation and benzylation reactions in academic and industrial research laboratories.
• Fine Chemical Production: Integral to the manufacture of dyes, pigments, and other performance chemicals requiring tailored steric and electronic properties.

Basic Information

Product Name	2,4,6-Triisopropylbenzyl Chloride
CAS No.	38580-86-8
Molecular Formula	C16H25Cl
Molecular Weight	252.82 g/mol
Synonyms	1-(Chloromethyl)-2,4,6-triisopropylbenzene; (2,4,6-Triisopropylphenyl)methyl chloride; TIPB-Cl; 2,4,6-Triisopropylbenzylchloride; Benzene, 1-(chloromethyl)-2,4,6-triisopropyl-; α-Chloro-2,4,6-triisopropyltoluene
EINECS	Contact for details

Quality Control

Every batch of 2,4,6-Triisopropylbenzyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.