Description

[(4-Methylphenyl)Sulfonyl]Methyltrifluoromethanesulfonate CAS NO 37891-93-3 is a specialized organosulfur triflate reagent, valued for its role as a versatile electrophilic methylating and sulfonylating agent in advanced organic synthesis. Its significance lies in enabling the construction of complex molecular architectures, particularly in the development of pharmaceuticals and agrochemicals. This high-purity intermediate is essential for research chemists and process development scientists in fine chemical, pharmaceutical R&D, and material science industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonamide or methyl ether functionalities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides that require specific sulfonyl or methyl group introductions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials where sulfone groups modify material properties.
• Cross-Coupling Reactions: Serves as an effective electrophile in palladium-catalyzed cross-coupling reactions for C-C and C-S bond formation.
• Protecting Group Chemistry: Utilized for the temporary protection of alcohols and amines as their sulfonate esters during multi-step synthetic sequences.
• Labeled Compound Synthesis: A precursor for introducing radiolabeled (e.g., tritium, carbon-14) or stable isotope-labeled methyl groups for metabolic and pharmacokinetic studies.

Basic Information

Item	Detail
Product Name	[(4-Methylphenyl)Sulfonyl]Methyltrifluoromethanesulfonate
CAS No.	37891-93-3
Molecular Formula	C10H11F3O5S2
Molecular Weight	332.31 g/mol
Synonyms	p-Toluenesulfonylmethyl Triflate; Tosylmethyl Trifluoromethanesulfonate; TsMethyl Triflate; (4-Methylbenzenesulfonyl)methyl Trifluoromethanesulfonate; Methyl(p-tolylsulfonyl)methyl Triflate; Methyl[(4-methylphenyl)sulfonyl]methyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid [(4-Methylphenyl)Sulfonyl]Methyl Ester
EINECS	Contact for details

Quality Control

Our [(4-Methylphenyl)Sulfonyl]Methyltrifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to guarantee reliable performance in your sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.