Description

(2E)-4,4-Difluoro-2-Butenoic Acid Ethyl Ester is a high-purity fluorinated organic building block of significant commercial interest. This compound is valued for its unique chemical reactivity, serving as a versatile synthon for introducing difluoroalkene and difluoromethyl motifs into complex molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, leveraging the difluoroalkene unit to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorine incorporation enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and advanced materials with tailored surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, cycloadditions, and other transformations to construct complex, fluorinated organic molecules in R&D settings.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research focused on developing new fluorination methodologies and understanding structure-activity relationships.

Basic Information

Product Name	(2E)-4,4-Difluoro-2-Butenoic Acid Ethyl Ester
CAS No.	37746-82-0
Molecular Formula	C6H8F2O2
Molecular Weight	150.12 g/mol
Synonyms	Ethyl (2E)-4,4-Difluoro-2-butenoate; Ethyl 4,4-Difluoro-2-butenoate; 4,4-Difluoro-2-butenoic Acid Ethyl Ester; (E)-Ethyl 4,4-difluorobut-2-enoate; trans-4,4-Difluoro-2-butenoic Acid Ethyl Ester; 37746-82-0; DFBE-Et
EINECS	Contact for details

Quality Control

Our (2E)-4,4-Difluoro-2-Butenoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat and ignition sources. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity ((E)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.