Description

n-Octadecanoyl-L-Phenylalanine is a high-purity, synthetic lipoamino acid conjugate derived from the amide linkage of stearic acid and L-phenylalanine. This compound is valued for its unique amphiphilic properties, combining a long hydrophobic alkyl chain with a chiral amino acid headgroup, making it a versatile building block for advanced formulations. It is primarily sought by research and development teams in the pharmaceutical, cosmetic, and specialty chemical industries for applications in drug delivery systems, biomimetic materials, and as a bioactive intermediate.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel peptide-based therapeutics and prodrugs to enhance lipophilicity and membrane permeability.
• Cosmetic Actives: Serves as a key ingredient in anti-aging and skin-repair formulations, functioning as a biomimetic ceramide analog to reinforce the skin barrier.
• Drug Delivery Systems: Incorporated into lipid nanoparticles (LNPs), liposomes, and micelles as a structural component to improve drug loading and targeted release.
• Biomaterial Research: Employed in the development of self-assembling hydrogels, coatings, and scaffolds for tissue engineering and regenerative medicine.
• Surfactant & Emulsifier: Acts as a specialty, biocompatible surfactant in high-value emulsion systems for personal care and agrochemicals.
• Biochemical Research: Utilized as a standard or substrate in enzymatic studies and metabolic pathway research due to its specific chiral configuration.

Basic Information

Product Name	n-Octadecanoyl-L-Phenylalanine
CAS No.	37571-95-2
Molecular Formula	C₂₇H₄₅NO₃
Molecular Weight	431.65 g/mol
Synonyms	N-Stearoyl-L-phenylalanine; L-Phenylalanine, N-(1-oxooctadecyl)-; N-Octadecanoylphenylalanine; Stearic acid phenylalanine amide; N-(1-Oxooctadecyl)-L-phenylalanine; Stearoyl phenylalanine; Lipophilic phenylalanine derivative
EINECS	Contact for details

Quality Control

Our n-Octadecanoyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and commercial use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: -10.0° to -15.0° (c=1 in CHCl₃)
Melting Point	95°C - 105°C
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.