Description

Kryptofix 111 is a specialized macrocyclic polyether, also known as a cryptand, widely recognized as a powerful phase-transfer catalyst and complexing agent. Its primary value lies in its ability to selectively bind alkali metal cations, significantly enhancing reaction rates and yields in various synthetic processes. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for nucleophilic fluorination reactions and other sensitive organometallic syntheses. We supply Kryptofix 111 CAS NO 37095-49-1 to the global market, ensuring consistent quality and reliable availability for critical applications.

Application

• Nucleophilic Fluorination Reactions: A key catalyst in the preparation of 18F-labeled radiopharmaceuticals for Positron Emission Tomography (PET) imaging.
• Phase-Transfer Catalysis (PTC): Facilitates reactions between reagents in immiscible phases, improving efficiency in alkylation, esterification, and oxidation processes.
• Alkali Metal Ion Complexation: Used to solubilize alkali metal salts in organic solvents for use in organometallic synthesis and polymerization initiators.
• Chemical Synthesis: Enables milder reaction conditions and higher selectivity in the synthesis of fine chemicals, pharmaceuticals, and specialty polymers.
• Analytical Chemistry: Serves as a masking agent or ionophore in sensors and selective electrodes for cation detection.
• Materials Science: Employed in the development of advanced materials, including liquid crystals and supramolecular assemblies.

Basic Information

Product Name	Kryptofix 111
CAS No.	37095-49-1
Molecular Formula	C18H36N2O6
Molecular Weight	376.49 g/mol
Synonyms	4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane; Kryptofix® 2.2.2; Kryptofix 222; 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane; Cryptand 222; K-222; [2.2.2]Cryptand; 1,10-Diaza-4,7,13,16,21,24-hexaoxabicyclo[8.8.8]hexacosane
EINECS	253-349-2

Quality Control

Our Kryptofix 111 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with every shipment. We can supply material compliant with various pharmacopeial and customer-specific specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed after opening to prevent degradation from atmospheric moisture and light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.