Description

Heptamethyldisilazane is a versatile organosilicon compound, widely recognized as a highly effective silylating agent and protecting group reagent in synthetic chemistry. Its primary value lies in its ability to introduce the trimethylsilyl (TMS) group, protecting reactive sites like hydroxyl and amino groups to enable complex multi-step syntheses. This makes it an indispensable material for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for producing active pharmaceutical ingredients (APIs), specialty polymers, and silicon-based coatings.

Application

• Pharmaceutical Synthesis: As a key silylating agent for protecting sensitive functional groups (e.g., -OH, -NH) during the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of advanced pesticides and herbicides where silicon incorporation can enhance stability and bioavailability.
• Surface Modification & Coatings: Employed as a precursor or coupling agent to modify surface properties of silica, metals, and polymers, improving adhesion, hydrophobicity, or release characteristics.
• Silicon Polymer Chemistry: Serves as a capping agent or chain terminator in the production of polysiloxanes (silicones) and other silicon-based polymers to control molecular weight and end-group functionality.
• Chemical Derivatization for Analysis: Utilized in gas chromatography (GC) and mass spectrometry (MS) to derivative polar compounds (e.g., sugars, alcohols) for improved volatility and detection.
• Electronics & Semiconductor Industry: Applied in chemical vapor deposition (CVD) processes as a silicon and nitrogen source for depositing silicon nitride or silicon carbonitride thin films.

Basic Information

Product Name	Heptamethyldisilazane
CAS No.	37074-17-2
Molecular Formula	C7H21NSi2
Molecular Weight	175.43 g/mol
Synonyms	1,1,1,3,3,3-Hexamethyl-2-(trimethylsilyl)disilazane; Bis(trimethylsilyl)methylamine; HMDS-NMe; N-Methyl-1,1,1,3,3,3-hexamethyldisilazane; N-Methylbis(trimethylsilyl)amine; N-Trimethylsilyl-N-methyltrimethylsilylamine; Methyl heptamethyldisilazane
EINECS	253-336-5

Quality Control

Our Heptamethyldisilazane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including gas chromatography (GC) for assay and impurity profiling, to meet exacting customer specifications. A detailed Certificate of Analysis (COA) providing full analytical results is supplied with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.1%
Density (at 20°C)	0.77 - 0.79 g/mL
Refractive Index (n20D)	1.407 - 1.409

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.