Description

1-Chloro-4-(Iodomethyl)Benzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional structure, featuring both a reactive benzyl iodide and an aryl chloride moiety, makes it a critical intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic or benzyl-substituted structures.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the chloromethyl and iodomethyl groups enable further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Monomer: Employed in the creation of novel polymers and liquid crystals, where its aromatic core and reactive sites contribute to desired material properties.
• Cross-Coupling Reactions: The iodide functionality is highly reactive in palladium-catalyzed cross-couplings (e.g., Suzuki, Stille, Negishi), while the chloride offers a site for subsequent modification.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	1-Chloro-4-(Iodomethyl)Benzene
CAS No.	35424-56-7
Molecular Formula	C7H6ClI
Molecular Weight	252.48 g/mol
Synonyms	4-Chlorobenzyl Iodide; p-Chlorobenzyl Iodide; (4-Chlorophenyl)methyl Iodide; 1-(Iodomethyl)-4-chlorobenzene; α-Iodo-4-chlorotoluene; 4-Chloro-α-iodotoluene; 35424-56-7; p-Chloro-α-iodotoluene
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-(Iodomethyl)Benzene is produced under stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system supports cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging. Handle and store under an inert atmosphere if long-term stability is required.

Specification

Item	Specification
Appearance	White to pale yellow crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.