Description

trans-Cyclobutane-1,2-Diol CAS NO 35358-34-0 is a high-purity, stereochemically defined cyclobutane derivative that serves as a valuable chiral building block and synthetic intermediate. Its rigid, strained four-membered ring structure imparts unique steric and electronic properties, making it a critical component in advanced organic synthesis and pharmaceutical research. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise molecular scaffolds for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where its structural rigidity can influence biological activity.
• Ligand and Catalyst Development: Employed as a backbone for creating chiral ligands used in asymmetric catalysis, such as hydrogenation and cross-coupling reactions.
• Polymer Science: Acts as a monomer or cross-linking agent for producing specialty polymers with enhanced thermal and mechanical properties.
• Academic & R&D: A valuable tool in organic chemistry research for studying ring strain, stereochemistry, and novel reaction pathways.
• Flavor & Fragrance Industry: Potential use as a precursor for synthesizing specific odorants and flavorants with unique sensory profiles.

Basic Information

Product Name	trans-Cyclobutane-1,2-Diol
CAS No.	35358-34-0
Molecular Formula	C4H8O2
Molecular Weight	88.11 g/mol
Synonyms	(1R,2R)-Cyclobutane-1,2-diol; (1S,2S)-Cyclobutane-1,2-diol; trans-1,2-Cyclobutanediol; rac-trans-1,2-Cyclobutanediol; (±)-trans-1,2-Cyclobutanediol; DL-trans-1,2-Cyclobutanediol; Cyclobutane-1,2-diol, trans-; 1,2-trans-Dihydroxycyclobutane
EINECS	Contact for details

Quality Control

Our trans-Cyclobutane-1,2-Diol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet the stringent requirements of research and industrial applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which may affect product quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% trans-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.