Description

trans-3-Chlorocyclobutanecarboxylic Acid is a high-purity, synthetically valuable chiral building block featuring a cyclobutane ring system. This compound is essential for advanced organic synthesis, particularly in pharmaceutical research and development, where it serves as a key intermediate for constructing complex molecules with defined stereochemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functionalized cyclobutane motifs into new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the cyclobutane core can contribute to unique biological activity and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the synthesis of monomers and polymers with rigid, strained ring structures to engineer materials with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized to create tagged molecules or probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	trans-3-Chlorocyclobutanecarboxylic Acid
CAS No.	35207-70-6
Molecular Formula	C5H7ClO2
Molecular Weight	134.56 g/mol
Synonyms	(1r,3r)-3-Chlorocyclobutanecarboxylic Acid; trans-3-Chlorocyclobutan-1-carboxylic Acid; (R,R)-3-Chlorocyclobutanecarboxylic Acid; rel-(1R,3R)-3-Chlorocyclobutanecarboxylic Acid; 3-Chlorocyclobutanecarboxylic Acid (trans-); Cyclobutanecarboxylic acid, 3-chloro-, trans-; 35207-70-6
EINECS	Contact for details

Quality Control

Our trans-3-Chlorocyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.