Description

4-[(S)-1-Methylpropyl]-2,3-Dihydrofuran is a chiral, non-racemic heterocyclic compound featuring a tetrahydrofuran ring substituted with a sec-butyl group in the (S)-configuration. This specific stereochemistry makes it a valuable chiral building block and intermediate in asymmetric synthesis for the pharmaceutical and fine chemical industries. It is primarily sought after by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where precise stereocontrol is critical.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides and pesticides, where the biological activity is often specific to one stereoisomer.
• Ligand and Catalyst Preparation: Acts as a precursor for chiral ligands used in transition metal catalysis, such as asymmetric hydrogenation and cross-coupling reactions.
• Flavor and Fragrance Chemistry: Employed in the research and synthesis of chiral aroma chemicals and natural product analogs.
• Material Science Research: Investigated as a monomer or modifying agent for creating polymers with specific chiral or structural properties.
• Academic and R&D Laboratories: A critical reagent for methodological studies in organic synthesis and stereochemistry.

Basic Information

Product Name	4-[(S)-1-Methylpropyl]-2,3-Dihydrofuran
CAS No.	34379-54-9
Molecular Formula	C8H14O
Molecular Weight	126.20 g/mol
Synonyms	(S)-4-sec-Butyl-2,3-dihydrofuran; (S)-4-(1-Methylpropyl)-2,5-dihydrofuran; (S)-2,3-Dihydro-4-(1-methylpropyl)furan; (S)-4-(sec-Butyl)-2,3-dihydrofuran; 2,3-Dihydro-4-[(1S)-1-methylpropyl]furan; (S)-(-)-4-sec-Butyl-2,3-dihydrofuran; 4-[(1S)-1-Methylpropyl]-2,3-dihydrofuran
EINECS	Contact for details

Quality Control

Our 4-[(S)-1-Methylpropyl]-2,3-Dihydrofuran is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC or GC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; it is recommended to store under an inert atmosphere such as nitrogen for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.