Description

Silychristin CAS NO 33889-69-9 is a specific flavonolignan compound, a key constituent of the standardized extract derived from the milk thistle plant (*Silybum marianum*). This high-purity reference standard is critical for research, quality control, and the development of nutraceutical and pharmaceutical products. It is primarily sought by analytical laboratories, R&D departments in the dietary supplement industry, and manufacturers of botanical extracts for use in identification, assay development, and as a calibration standard.

Application

• Analytical Reference Standard: Primary use as a high-purity certified reference material (CRM) for quantitative and qualitative analysis in HPLC, UPLC, and LC-MS methods.
• Phytopharmaceutical Research: Used in pharmacological studies to investigate the individual bioactivity, metabolism, and synergistic effects of milk thistle flavonolignans.
• Dietary Supplement QC/QA: Essential for the standardization and potency verification of milk thistle extracts (Silymarin) in finished nutraceutical products.
• Botanical Extract Manufacturing: Serves as a benchmark for process optimization and quality control during the extraction and purification of Silymarin.
• Method Development & Validation: Critical for developing and validating compendial (e.g., USP, EP) or in-house analytical methods for flavonolignan content.
• Stability Studies: Employed as a marker compound to assess the shelf-life and degradation profile of milk thistle-based formulations.

Basic Information

Product Name	Silychristin
CAS No.	33889-69-9
Molecular Formula	C25H22O10
Molecular Weight	482.44 g/mol
Synonyms	Silychristin; Silichristin; 3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4-chromanone; 6-[3-(4-Hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; Flavonolignan B; Milk Thistle Flavonolignan
EINECS	Contact for details

Quality Control

Our Silychristin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and easily oxidized; containers should be sealed under an inert atmosphere after opening and desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.