Description

1-O,2-O,3-O,4-O,5-o-Pentakis(Trimethylsilyl)-D-Glucitol 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a fully silylated derivative of D-glucitol, featuring a protected phosphate group at the 6-position. This compound is a critical advanced synthetic intermediate and protecting group reagent, valued for its ability to impart solubility and stability in non-polar media. It is primarily needed by researchers and manufacturers in nucleoside chemistry, carbohydrate research, and pharmaceutical development for the synthesis of complex biomolecules.

Application

• Synthesis of Nucleotide Analogs: Serves as a key phosphorylating or protecting group reagent in the preparation of modified nucleosides and nucleotides for antiviral and anticancer drug candidates.
• Carbohydrate Chemistry Intermediate: Used in the stepwise synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics where selective protection is required.
• Pharmaceutical Research: Acts as a building block for prodrug development, particularly for compounds requiring masked phosphate groups for enhanced bioavailability.
• Derivatization Agent for GC/MS: Employed in analytical chemistry to derivative polar, multifunctional compounds like sugars and polyols for gas chromatographic analysis.
• Material Science Research: Potential monomer or cross-linker in the development of specialty silicones or hybrid organic-inorganic polymers.
• Bioconjugation Chemistry: Facilitates the site-specific modification of biomolecules through its reactive silyl and phosphate groups.

Basic Information

Product Name	1-O,2-O,3-O,4-O,5-o-Pentakis(Trimethylsilyl)-D-Glucitol 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	33800-35-0
Molecular Formula	C27H67O9PSi7
Molecular Weight	787.43 g/mol
Synonyms	D-Glucitol, 1,2,3,4,5-pentakis-O-(trimethylsilyl)-, 6-(bis(trimethylsilyl) phosphate); Hexa(trimethylsilyl) D-Glucitol Phosphate; Per-O-trimethylsilyl D-Glucitol 6-Phosphate; TMS-Glucitol Phosphate; 1,2,3,4,5-Penta-O-trimethylsilyl-D-glucitol 6-(bis(trimethylsilyl) phosphate); Fully Protected D-Glucitol Phosphate Ester; Hexakis(trimethylsilyl) Sorbitol Phosphate
EINECS	Contact for details

Quality Control

Our production of this high-value specialty chemical adheres to strict in-process controls to ensure batch-to-batch consistency and identity. Each lot is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ³¹P), HPLC, and GC to confirm structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, identity, and impurity profile is provided with every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Keep away from strong acids and organic solvents. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.