Description

2-(4-p-Tolyl-Tetrahydro-2H-Pyran-4-Yl)Acetic Acid is a specialized organic compound featuring a tetrahydro-2H-pyran ring substituted with a p-tolyl group and an acetic acid moiety, making it a valuable chiral building block and intermediate. This structural complexity provides significant utility in advanced synthetic chemistry, particularly for constructing molecules with specific stereochemistry and functional group arrays. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and sophisticated fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, including potential central nervous system (CNS) drugs and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its specific stereochemistry can influence biological activity and selectivity.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to control reaction stereoselectivity.
• Material Science Research: Employed in the synthesis of functionalized polymers or liquid crystals, where the aromatic and polar groups can modify material properties.
• Academic & Industrial R&D: A crucial compound for methodological studies in organic synthesis, including ring-forming reactions and stereocontrolled transformations.

Basic Information

Product Name	2-(4-p-Tolyl-Tetrahydro-2H-Pyran-4-Yl)Acetic Acid
CAS No.	33451-58-0
Molecular Formula	C14H18O3
Molecular Weight	234.29 g/mol
Synonyms	2-[4-(4-Methylphenyl)oxan-4-yl]acetic acid; 2-(4-p-Tolyltetrahydro-2H-pyran-4-yl)acetic Acid; 2-(4-(p-Tolyl)tetrahydro-2H-pyran-4-yl)acetic Acid; 4-(4-Methylphenyl)tetrahydro-2H-pyran-4-acetic Acid; 2-(4-(4-Methylphenyl)tetrahydro-2H-pyran-4-yl)acetic Acid; 2-(4-(p-Tolyl)tetrahydropyran-4-yl)acetic Acid; 33451-58-0; Acetic acid, 2-[4-(4-methylphenyl)tetrahydro-2H-pyran-4-yl]-
EINECS	Contact for details

Quality Control

Our 2-(4-p-Tolyl-Tetrahydro-2H-Pyran-4-Yl)Acetic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.