Description

11β,17-Bis(Trimethylsiloxy)-5α-Androst-2-Ene is a high-purity, organosilicon-protected steroid derivative, serving as a critical advanced intermediate in pharmaceutical synthesis. Its primary value lies in enabling precise chemical transformations for the development of novel therapeutic agents, particularly in the field of endocrinology. This compound is essential for research institutions and pharmaceutical manufacturers focused on creating and scaling up production of steroidal drugs and hormone analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Hormone Analog Research: Used in R&D for developing novel androgen and corticosteroid receptor modulators.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP manufacturing of steroidal compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for studying steroid chemistry and metabolic pathways.

Basic Information

Product Name	11β,17-Bis(Trimethylsiloxy)-5α-Androst-2-Ene
CAS No.	33283-02-2
Molecular Formula	C27H50O2Si2
Molecular Weight	462.87 g/mol
Synonyms	5α-Androst-2-ene-11β,17β-diol, 11β,17β-bis(trimethylsilyl) ether; 11β,17β-Bis-O-(trimethylsilyl)-5α-androst-2-ene; Androst-2-ene-11β,17β-diol, bis(trimethylsilyl) ether; 11β,17β-Di-O-trimethylsilyl-5α-androst-2-ene; 5α-Androst-2-en-11β,17β-diol bis(trimethylsilyl) ether; 11β,17β-Bis(trimethylsiloxy)-5α-androst-2-ene; Steroid silyl ether intermediate
EINECS	Contact for details

Quality Control

Our 11β,17-Bis(Trimethylsiloxy)-5α-Androst-2-Ene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by FT-IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.