Description

3,6-Difluoropyridazine CAS NO 33097-39-1 is a high-purity fluorinated heterocyclic building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for introducing the difluoropyridazine moiety into complex molecular architectures, enabling the fine-tuning of physicochemical properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically relevant scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoropyridazine unit can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, ligands for catalysis, and organic electronic materials due to its unique electronic properties.
• Liquid Crystal & OLED Development: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) to modify polarity and stability.
• Chemical Biology & Probe Development: Utilized as a versatile handle for creating biochemical probes and tags for imaging and diagnostic applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems.

Basic Information

Product Name	3,6-Difluoropyridazine
CAS No.	33097-39-1
Molecular Formula	C4H2F2N2
Molecular Weight	116.07 g/mol
Synonyms	3,6-Difluoropyridazine; 3,6-Difluoro-1,2-diazine; 3,6-Difluoro-1,2-diazabenzene; Pyridazine, 3,6-difluoro-; 1,2-Diazine, 3,6-difluoro-; NSC 403119; 33097-39-1
EINECS	Contact for details

Quality Control

Our 3,6-Difluoropyridazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride/strong alkali sensitivity, ensure proper segregation in storage areas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.