Description

3-Chloro-6-Fluoropyridazine is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chlorine and fluorine substituents on the pyridazine ring, makes it a key intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyridazine core contributes to biological activity.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Employed as a reactive handle in the design of molecular probes, tags, and linkers for studying biological systems.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the pyridazine moiety into more complex structures.
• Nucleophilic Aromatic Substitution: The chlorine and fluorine atoms are susceptible to displacement by various nucleophiles, enabling diverse functionalization.

Basic Information

Product Name	3-Chloro-6-Fluoropyridazine
CAS No.	33097-38-0
Molecular Formula	C4H2ClFN2
Molecular Weight	132.52 g/mol
Synonyms	6-Fluoro-3-chloropyridazine; 3-Chloro-6-fluoropyridazine; 3-Chloro-6-fluoro-1,2-diazine; Fluorochloropyridazine; 33097-38-0; 3-Chloro-6-fluoro-1,2-diazabenzene; 3-Chloro-6-fluoropyridazin; 3-Chloro-6-fluoro-pyridazine
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-6-Fluoropyridazine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA), including results from HPLC, GC, NMR, and mass spectrometry, is supplied with each shipment to guarantee identity, purity, and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.