Description

2-Hydroxymethyl-2-O:5-o-Bis(p-Tolylsulfonyl)-3-Deoxy-D-Erythro-Pentonic Acid γ-Lactone is a specialized, high-purity organic intermediate featuring a unique lactone structure protected by tosyl groups. This compound is critical for synthetic chemists requiring precise stereochemical control and selective deprotection in complex multi-step syntheses. It is primarily utilized in advanced pharmaceutical research and development, particularly for the synthesis of nucleoside analogs, carbohydrate-based therapeutics, and other fine chemicals where its protected functionality is essential.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Carbohydrate Chemistry: Used in the stereoselective synthesis of complex sugars, deoxy sugars, and glycomimetics due to its protected lactone form.
• Chemical Biology Probes: Serves as a precursor for labeled or modified sugar derivatives used in metabolic pathway studies and probe development.
• Process Development: Employed in route scouting and optimization for the commercial-scale production of high-value active pharmaceutical ingredients (APIs).
• Academic & Industrial Research: A valuable reagent for methodological studies in organic synthesis, particularly in protecting group strategies and lactone chemistry.

Basic Information

Product Name	2-Hydroxymethyl-2-O:5-o-Bis(p-Tolylsulfonyl)-3-Deoxy-D-Erythro-Pentonic Acid γ-Lactone
CAS No.	32976-18-4
Molecular Formula	C21H24O9S2
Molecular Weight	484.54 g/mol
Synonyms	2-Hydroxymethyl-2,5-di-O-tosyl-3-deoxy-D-erythro-pentono-1,4-lactone; 3-Deoxy-2-C-(hydroxymethyl)-2,5-di-O-(p-tolylsulfonyl)-D-erythro-pentono-1,4-lactone; 2,5-Di-O-tosyl-3-deoxy-2-C-hydroxymethyl-D-erythro-pentono-1,4-lactone; D-erythro-Pentono-1,4-lactone, 3-deoxy-2-C-(hydroxymethyl)-2,5-bis-O-[(4-methylphenyl)sulfonyl]-; Tosylated Deoxy Pentonic Acid Lactone Derivative
EINECS	Contact for details

Quality Control

Our 2-Hydroxymethyl-2-O:5-o-Bis(p-Tolylsulfonyl)-3-Deoxy-D-Erythro-Pentonic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full batch traceability are provided to guarantee reproducible quality and supply reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.