Description

Pentafluorobenzyl p-Toluenesulfonate is a specialized fluorinated organic compound that serves as a versatile reagent in advanced chemical synthesis. Its primary value lies in its role as a highly effective pentafluorobenzylating agent, introducing the electron-withdrawing and chemically stable pentafluorobenzyl group into target molecules. This product is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel intermediates, develop active ingredients, and synthesize compounds for analytical derivatization.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the pentafluorobenzyl protecting group or moiety in the development of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel fluorinated pesticides and herbicides, where the pentafluorobenzyl group can enhance biological activity and stability.
• Analytical Chemistry Derivatization: Employed to derivative compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis, improving detection sensitivity and volatility.
• Material Science Precursor: Acts as a building block for synthesizing fluorinated polymers, liquid crystals, or specialty materials with unique surface properties.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds in complex molecule assembly.
• Radiochemistry & Tracer Development: Potential use in the synthesis of fluorinated tracers for Positron Emission Tomography (PET) imaging agents.

Basic Information

Item	Detail
Product Name	Pentafluorobenzyl p-Toluenesulfonate
CAS No.	32974-36-0
Molecular Formula	C14H9F5O3S
Molecular Weight	352.28 g/mol
Synonyms	Pentafluorobenzyl Tosylate; 2,3,4,5,6-Pentafluorobenzyl 4-Methylbenzenesulfonate; α,α,α,2,3,4,5,6-Octafluoro-p-tolyl p-Toluenesulfonate; Pentafluorobenzyl p-Tosylate; PFB-Ts; Pentafluorobenzyl Tosylate Ester; 4-Methylbenzenesulfonic Acid Pentafluorobenzyl Ester; (Pentafluorobenzyloxy)tosyl
EINECS	Contact for details

Quality Control

Our Pentafluorobenzyl p-Toluenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.