Description

(S)-5-Hydroxymethyldihydrofuran-2-One is a high-value chiral lactone derivative, serving as a critical building block in advanced organic synthesis. Its importance lies in its role as a versatile precursor for synthesizing complex molecules with defined stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside analogs, antiviral drugs, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides.
• Fine Chemical Production: Serves as a starting material for flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial Research: A valuable reagent in methodological development for asymmetric synthesis and catalysis studies.
• Bioconjugate Chemistry: Potential use in linking molecules due to its reactive hydroxyl and lactone functionalities.

Basic Information

Product Name	(S)-5-Hydroxymethyldihydrofuran-2-One
CAS No.	32780-06-6
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	(S)-(-)-5-Hydroxymethylbutyrolactone; (S)-5-Hydroxymethyl-γ-butyrolactone; (S)-HMBL; (S)-Tetrahydro-5-(hydroxymethyl)-2-furanone; (3S)-5-(Hydroxymethyl)oxolan-2-one; (S)-γ-Hydroxymethyl-γ-butyrolactone; L-(-)-5-Hydroxymethylbutyrolactone
EINECS	Contact for details

Quality Control

Our (S)-5-Hydroxymethyldihydrofuran-2-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.