Description

3-[Bis(Trimethylsilyl)Amino]-1-(Trimethylsilyl)Pyrrolidin-2-One is a highly functionalized silylated pyrrolidinone derivative, serving as a versatile and protected intermediate in advanced organic synthesis. Its value lies in providing a sterically hindered, moisture-sensitive nitrogen source and a reactive carbonyl group, enabling precise molecular construction under controlled conditions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where the introduction of a protected amino-lactam moiety is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, including protease inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in creating advanced pesticide and herbicide molecules that require specific lactam or silylated amine functionalities.
• Organosilicon Chemistry: Acts as a precursor for introducing multiple trimethylsilyl groups into target molecules, modifying their reactivity and physical properties.
• Peptidomimetic Research: Serves as a constrained scaffold or protecting group strategy in the design of peptide analogs and bioisosteres.
• Material Science: Potential monomer or modifier in the development of specialized silicon-based polymers and coatings.
• Academic & R&D: Valuable reagent for methodological development in synthetic organic chemistry, especially in reactions involving sensitive organometallic species.

Basic Information

Product Name	3-[Bis(Trimethylsilyl)Amino]-1-(Trimethylsilyl)Pyrrolidin-2-One
CAS No.	32565-11-0
Molecular Formula	C13H32N2OSi3
Molecular Weight	316.67 g/mol
Synonyms	1-(Trimethylsilyl)-3-[bis(trimethylsilyl)amino]-2-pyrrolidinone; 3-[Bis(trimethylsilyl)amino]-1-(trimethylsilyl)-2-pyrrolidinone; N,N-Bis(trimethylsilyl)-1-(trimethylsilyl)-3-amino-2-pyrrolidinone; TMS-protected 3-amino-1-(TMS)-2-pyrrolidinone; Tris(trimethylsilyl) amino lactam; 32565-11-0; 3-(Bis(trimethylsilyl)amino)-1-(trimethylsilyl)pyrrolidin-2-one
EINECS	Contact for details

Quality Control

Our 3-[Bis(Trimethylsilyl)Amino]-1-(Trimethylsilyl)Pyrrolidin-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized by advanced analytical techniques including NMR, GC, and HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, this product should be handled and stored under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.