Description

2-O,3-O,6-o-Trimethyl-1-O,4-o-Bis(Trimethylsilyl)-D-Glucopyranose is a key protected sugar derivative, specifically a per-silylated and methylated glucopyranose, that serves as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in providing a versatile, selectively protected scaffold for the controlled synthesis of complex carbohydrates, glycoconjugates, and nucleoside analogs. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for glycosylation reactions and the development of bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel glycosylated drugs, prodrugs, and antiviral/antibiotic agents.
• Carbohydrate Chemistry Research: Used as a protected donor or acceptor in glycosylation studies to construct oligosaccharides with specific linkages.
• Glycoconjugate Synthesis: Serves as a precursor for creating glycopeptides, glycolipids, and other biologically active conjugates for drug discovery.
• Nucleoside & Nucleotide Analog Development: Employed in the modification of sugar moieties to create novel therapeutic nucleoside analogs.
• Agrochemical Active Ingredient Synthesis: Used in the research and development of new generation pesticides and plant growth regulators with carbohydrate-based structures.
• Chiral Pool Starting Material: Provides a readily available, enantiomerically pure chiral template for asymmetric synthesis in fine chemical production.
• Material Science: Potential monomer or modifier for creating specialized polymers and surfaces with carbohydrate functionality.

Basic Information

Item	Details
Product Name	2-O,3-O,6-o-Trimethyl-1-O,4-o-Bis(Trimethylsilyl)-D-Glucopyranose
CAS No.	32388-39-9
Molecular Formula	C15H34O6Si2
Molecular Weight	366.60 g/mol
Synonyms	1,4-Bis-O-(trimethylsilyl)-2,3,6-tri-O-methyl-D-glucopyranose; D-Glucopyranose, 1,4-bis-O-(trimethylsilyl)-2,3,6-tri-O-methyl-; 2,3,6-Tri-O-methyl-1,4-bis-O-(trimethylsilyl)-D-glucopyranose; Per-O-methylated, per-O-silylated D-glucose derivative; TMS-protected methyl glucoside; TMSEtGlc(OMe)3 (common abbreviation); Protected D-glucose building block
EINECS	Contact for details

Quality Control

Our 2-O,3-O,6-o-Trimethyl-1-O,4-o-Bis(Trimethylsilyl)-D-Glucopyranose is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR (¹H & ¹³C) for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions, preferably in a glovebox or under an inert atmosphere (nitrogen/argon) when opening the primary container for use, to prevent hydrolysis of the silyl protecting groups.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.