Description

1-Bromocyclobutane-1-Carboxylic Acid is a versatile brominated carboxylic acid building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a reactive bromine atom and a carboxylic acid functional group on the same cyclobutane ring, makes it a critical precursor for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries, where it is used to introduce the strained cyclobutyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting cyclobutane-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclobutyl group can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Employed as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Monomer: Acts as a functional monomer for creating polymers with unique thermal and mechanical properties derived from the strained four-membered ring.
• Chemical Biology Probe Synthesis: Utilized to build molecular probes and tags for studying biological systems and protein interactions.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.

Basic Information

Item	Detail
Product Name	1-Bromocyclobutane-1-Carboxylic Acid
CAS No.	32122-23-9
Molecular Formula	C5H7BrO2
Molecular Weight	179.01 g/mol
Synonyms	1-Bromocyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 1-bromo-; 1-Bromo-1-cyclobutanecarboxylic Acid; (1-Bromocyclobutyl)formic Acid; α-Bromocyclobutanecarboxylic Acid; Bromocyclobutanecarboxylic Acid; 32122-23-9 (CAS)
EINECS	Contact for details

Quality Control

Our 1-Bromocyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing identity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acid nature, store separately from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.