Description

o-2-Methoxyphenyl Chlorothioformate is a specialized organosulfur reagent featuring a chlorothioformate functional group ortho to a methoxy substituent on an aromatic ring. This molecular architecture makes it a valuable building block for synthesizing more complex sulfur-containing compounds, particularly thioesters and thiocarbamates. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates. Its reactivity profile allows for selective functionalization, enabling the development of compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those requiring a thioester or thiocarbamate pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the sulfur moiety enhances activity.
• Chemical Research & Development: A versatile reagent for academic and industrial research in organic synthesis, especially in methodologies involving sulfur transfer.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized ligands or catalysts used in asymmetric synthesis and metal complexation.
• Polymer Modification: Can be employed to introduce reactive thiol or thioester groups into polymer chains for functional materials.
• Peptide Mimetics: Useful in the design and synthesis of peptide analogs where the thioester linkage can mimic or replace traditional amide bonds.

Basic Information

Product Name	o-2-Methoxyphenyl Chlorothioformate
CAS No.	31836-28-9
Molecular Formula	C8H7ClO2S
Molecular Weight	202.66 g/mol
Synonyms	2-Methoxyphenyl Chlorothioformate; o-Methoxyphenyl Chlorothioformate; (2-Methoxyphenyl) Carbonochloridothioate; Chlorothioformic Acid O-(2-Methoxyphenyl) Ester; 2-Methoxy Phenyl Chlorothioformate; 2-Methoxyphenyl Chlorothionoformate; o-Anisyl Chlorothioformate
EINECS	Contact for details

Quality Control

Our production of o-2-Methoxyphenyl Chlorothioformate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot undergoes comprehensive analytical testing, including purity assay and identification of key impurities. Certificates of Analysis (COA) detailing all test results are provided with every shipment and are available upon request to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.