Description

2-Hydroxy-2-(4-Methylphenyl)Acetic Acid is a versatile chiral α-hydroxy acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized aromatic scaffold with both hydroxyl and carboxylic acid groups, enabling precise molecular construction. This compound is essential for research and production in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and specialty intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), receptor agonists/antagonists, and other bioactive molecules.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for metal-catalyzed reactions, including hydrogenation and cross-coupling.
• Fine Chemical Synthesis: Employed in the production of complex fragrances, liquid crystals, and advanced polymer additives.
• Agrochemical Research: Acts as an intermediate in developing novel herbicides and plant growth regulators with specific stereochemistry.
• Academic & R&D: Serves as a standard or starting material in methodological studies for new synthetic routes and chiral resolution techniques.

Basic Information

Product Name	2-Hydroxy-2-(4-Methylphenyl)Acetic Acid
CAS No.	31284-89-6
Molecular Formula	C9H10O3
Molecular Weight	166.17 g/mol
Synonyms	(4-Methylphenyl)glycolic Acid; 2-(p-Tolyl)-2-hydroxyacetic Acid; p-Tolylglycolic Acid; α-Hydroxy-4-methylphenylacetic Acid; 2-Hydroxy-2-(p-tolyl)acetic Acid; (4-Methylbenzene)glycolic Acid; (±)-Mandelic Acid, 4-Methyl-; 4-Methylmandelic Acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-2-(4-Methylphenyl)Acetic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its acidic nature, ensure containers are made of compatible materials and are properly sealed to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Optical Purity (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.