Description

1,1,2,3-Tetramethylguanidine is a highly versatile and potent organic superbase, valued for its exceptional nucleophilicity and low nucleofugality. Its strong basicity in organic solvents makes it a superior catalyst and reagent for a wide range of synthetic transformations, offering advantages in reaction rate and selectivity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates efficient synthesis of complex molecules.

Application

• Pharmaceutical Synthesis: As a powerful non-nucleophilic base for deprotonation reactions, alkylations, and the synthesis of active pharmaceutical ingredients (APIs).
• Polymer Chemistry: Catalyst for the production of polyurethanes, polycarbonates, and other polymers, where it controls polymerization kinetics.
• Agrochemical Manufacturing: Key intermediate and catalyst in the synthesis of advanced pesticides, herbicides, and plant growth regulators.
• Organic Synthesis Reagent: Used in Knoevenagel condensations, Henry reactions, and other C-C bond forming reactions requiring strong base conditions.
• Ionic Liquid Research: Serves as a precursor or component in the development of novel ionic liquids for green chemistry applications.
• Chemical Research & Development: A valuable tool in medicinal chemistry and process development for exploring new synthetic pathways.

Basic Information

Product Name	1,1,2,3-Tetramethylguanidine
CAS No.	31081-16-0
Molecular Formula	C5H13N3
Molecular Weight	115.18 g/mol
Synonyms	1,1,2,3-Tetramethylguanidine; TMG; N,N,N',N'-Tetramethylguanidine; Tetramethylguanidine; Guanidine, N,N,N',N'-tetramethyl-; 1,1,3,3-Tetramethylguanidine (common misnomer); UNII-9J771K1S5P; NSC 66480
EINECS	250-459-0

Quality Control

Our 1,1,2,3-Tetramethylguanidine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. The product is hygroscopic; keep container tightly sealed when not in use to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0 %
Water Content (KF)	≤ 0.5 %
Refractive Index (n20D)	1.468 - 1.472
Density (20°C)	0.91 - 0.93 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.