Description

Phosphoric Acid 2-Trimethylsilyloxy-1-[(Trimethylsilyloxy)Methyl]Ethylbis(Trimethylsilyl) Ester is a highly specialized organosilicon-protected phosphate derivative, serving as a critical reagent in advanced synthetic chemistry. Its primary value lies in its role as a protected phosphoric acid equivalent, enabling precise phosphorylation reactions under mild conditions where the free acid would be incompatible. This compound is essential for researchers and process chemists in pharmaceutical development, nucleotide chemistry, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for introducing phosphate groups in drug candidates, particularly in prodrug development.
• Nucleotide & Oligonucleotide Chemistry: Used in the controlled synthesis of phosphate esters and phosphoramidites for DNA/RNA analogs.
• Peptide Modification: Enables site-specific phosphorylation of serine, threonine, or tyrosine residues in synthetic peptides.
• Material Science Precursor: Acts as a monomer or cross-linking agent for silicon-phosphate hybrid polymers and coatings.
• Catalyst and Ligand Preparation: Serves as a precursor for specialized phosphate-based ligands in homogeneous catalysis.
• Analytical Chemistry: Used as a derivatization agent for the GC or LC analysis of phosphate-containing compounds.

Basic Information

Item	Detail
Product Name	Phosphoric Acid 2-Trimethylsilyloxy-1-[(Trimethylsilyloxy)Methyl]Ethylbis(Trimethylsilyl) Ester
CAS No.	31038-12-7
Molecular Formula	C14H39O6PSi4
Molecular Weight	446.81 g/mol
Synonyms	Bis(trimethylsilyl) [2-[(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)ethyl] Phosphate; Tris(trimethylsilyl) Glycerol Phosphate; Glycerol 1-(Dihydrogen Phosphate) Tris(trimethylsilyl) Ether; 1,2,3-Tris-O-(trimethylsilyl)glycerol Cyclic Phosphate TMS Ester; TMS-Protected Glycerol Phosphate; Phosphoric Acid Tris(trimethylsilyl) Glycerol Ester
EINECS	Contact for details

Quality Control

Our production of this high-value synthetic intermediate adheres to stringent GMP-grade principles for non-pharmaceutical applications. Every batch is characterized by NMR (¹H, ¹³C, ³¹P), GC/HPLC for purity assessment, and Karl Fischer titration for moisture content, ensuring consistency for sensitive synthetic protocols. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.