Description

4-C-Cyclopropyl-1-O,2-o-Isopropylidene-α-D-Erythro-Tetrofuranose-3-Ulose is a sophisticated chiral building block and protected sugar derivative of significant interest in advanced organic synthesis. Its value lies in its highly functionalized, stereochemically defined structure, which serves as a key precursor for the development of novel nucleoside analogs, antiviral agents, and other bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to construct complex molecular architectures with precise stereocontrol.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Serves as a core scaffold in the development of next-generation antiviral therapeutics targeting viral polymerases.
• Agrochemical Synthesis: Used in the creation of chiral active ingredients for advanced crop protection agents.
• Fine Chemical Building Block: Employed in asymmetric synthesis to introduce the cyclopropyl and tetrofuranose motifs into complex target molecules.
• Glycochemistry & Glycobiology: Acts as a protected sugar derivative for studying carbohydrate-protein interactions and synthesizing complex oligosaccharides.
• Process Chemistry & Scale-Up: Suitable for development into a robust intermediate for kilogram-scale GMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-C-Cyclopropyl-1-O,2-o-Isopropylidene-α-D-Erythro-Tetrofuranose-3-Ulose
CAS No.	30645-00-2
Molecular Formula	C11H14O5
Molecular Weight	226.23 g/mol
Synonyms	4-C-Cyclopropyl-1,2-O-isopropylidene-α-D-erythro-tetrofuranose-3-ulose; 1,2-O-Isopropylidene-4-C-cyclopropyl-α-D-erythro-tetrofuranose-3-ulose; 4-C-Cyclopropyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose-3-ulose; Cyclopropyl C-nucleoside precursor; Protected cyclopropyl tetrofuranose ulose; 3-Keto-4-C-cyclopropyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate, ensuring batch-to-batch consistency and high purity suitable for research and development. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with specifications for key impurities and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and residual solvent levels is provided with each shipment. We support development toward GMP standards for critical pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; the container should be kept in a desiccated environment under an inert atmosphere for long-term storage to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.