Description

4-Bromo-2-Chlorophenol is a halogenated phenolic compound that serves as a versatile and critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This high-purity intermediate is essential for research and development chemists and production facilities specializing in active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the bromo-chloro-phenol moiety imparts specific biological activity.
• Dye and Pigment Manufacturing: Serves as a precursor for synthesizing halogenated dyes and pigments with enhanced color fastness and stability.
• Material Science: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new coupling reactions and synthesizing complex heterocycles.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	4-Bromo-2-Chlorophenol
CAS No.	3964-56-5
Molecular Formula	C6H4BrClO
Molecular Weight	207.45 g/mol
Synonyms	2-Chloro-4-bromophenol; 4-Bromo-2-chlorophenol; Phenol, 4-bromo-2-chloro-; 4-Bromo-o-chlorophenol; 2-Chloro-4-bromo-1-hydroxybenzene; NSC 403108; BRN 2040506; 4-Br-2-Cl-PhOH
EINECS	223-567-8

Quality Control

Our 4-Bromo-2-Chlorophenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment. We can support compliance requirements for various global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider packaging under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.