Description

6-Chloropyridazine-3-thiol is a versatile heterocyclic building block and key synthetic intermediate. Its core value lies in the reactive chlorothiol moiety, which enables selective functionalization for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with pyridazine-based scaffolds.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Chelator Precursor: Serves as a starting material for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized to develop molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis Building Block: Provides a versatile handle for medicinal chemistry and process R&D for structure-activity relationship (SAR) studies.

Basic Information

Product Name	6-Chloropyridazine-3-thiol
CAS No.	3916-78-7
Molecular Formula	C4H3ClN2S
Molecular Weight	146.60 g/mol
Synonyms	3-Chloro-6-mercaptopyridazine; 6-Chloro-3-pyridazinthiol; 6-Chloro-3-mercaptopyridazine; 3-Chloro-6-pyridazinethiol; 6-Chloro-3(2H)-pyridazinethione; 6-Chloro-3-pyridazinethiol; 6-Chloro-1,2-diazine-3-thiol; 6-Chloro-3-pyridazinyl mercaptan
EINECS	223-485-8

Quality Control

Our 6-Chloropyridazine-3-thiol is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.