Description

trans-4-Hydroxycyclohexanecarboxylic Acid is a versatile chiral building block and intermediate of significant importance in advanced organic synthesis. Its rigid cyclohexane backbone and functional groups make it a valuable precursor for creating complex molecular architectures with defined stereochemistry. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific stereochemical configurations.
• Liquid Crystal Materials: Serves as a core component in the manufacture of chiral dopants and monomers for liquid crystal displays (LCDs).
• Polymer Chemistry: Acts as a monomer or chain modifier for producing specialty polyesters and polyamides with enhanced thermal and mechanical properties.
• Asymmetric Catalysis: Employed as a ligand precursor or a scaffold for developing novel chiral catalysts and auxiliaries.
• Cosmetic & Personal Care Ingredients: Used in the synthesis of certain UV filters and skin-conditioning agents.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and material science research.

Basic Information

Product Name	trans-4-Hydroxycyclohexanecarboxylic Acid
CAS No.	3685-26-5
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	(1r,4r)-4-Hydroxycyclohexanecarboxylic Acid; trans-4-Hydroxycyclohexane-1-carboxylic Acid; (trans)-4-Hydroxy-1-cyclohexanecarboxylic Acid; 4-Hydroxycyclohexanecarboxylic Acid (trans); p-Hydroxycyclohexanecarboxylic Acid; HCA; Cyclohexanecarboxylic acid, 4-hydroxy-, trans-; 4-HCCA
EINECS	222-984-4

Quality Control

Our trans-4-Hydroxycyclohexanecarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.