Description

cis-4-Hydroxycyclohexanecarboxylic Acid is a versatile chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in the unique stereochemistry of the cis-configured hydroxyl and carboxylic acid functional groups on the cyclohexane ring, enabling the construction of complex, stereodefined molecular architectures. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries, where it serves as a precursor for active pharmaceutical ingredients (APIs), ligands, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of stereochemically pure drug candidates and active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Fine Chemical and Specialty Polymer Building Block: Incorporated into the structure of performance chemicals, liquid crystals, and advanced polymeric materials requiring specific stereochemistry.
• Academic and R&D Laboratories: Employed in methodological development and discovery chemistry for constructing complex natural product analogs and novel chemical entities.

Basic Information

Product Name	cis-4-Hydroxycyclohexanecarboxylic Acid
CAS No.	3685-22-1
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	(1r,4r)-4-Hydroxycyclohexanecarboxylic Acid; (1R,4R)-4-Hydroxycyclohexanecarboxylic Acid; trans-4-Hydroxycyclohexanecarboxylic Acid (Note: often refers to the same cis isomer in older literature); 4-Hydroxycyclohexanecarboxylic Acid, cis-; 4-Hydroxycyclohexane-1-carboxylic Acid; Cyclohexanecarboxylic acid, 4-hydroxy-, cis-; p-Hydroxycyclohexanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our cis-4-Hydroxycyclohexanecarboxylic Acid is produced under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), enantiomeric excess, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.