Description

4-o-Tolyl-Tetrahydro-Pyran-4-Carboxylic Acid is a versatile and synthetically valuable organic building block. This compound matters as a key chiral intermediate in the production of advanced pharmaceutical active ingredients and fine chemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of complex drug molecules, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its tetrahydro-pyran core structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the multi-step synthesis of flavors, fragrances, and other high-value specialty chemicals.
• Academic and Industrial Research: A valuable compound for methodological studies in organic synthesis, including novel cyclization and functionalization reactions.
• Material Science Precursor: Potential use in the development of advanced polymeric materials with specific thermal or optical properties.

Basic Information

Product Name	4-o-Tolyl-Tetrahydro-Pyran-4-Carboxylic Acid
CAS No.	3648-77-9
Molecular Formula	C14H16O3
Molecular Weight	232.28 g/mol
Synonyms	4-(2-Methylphenyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-(o-Tolyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-(2-Methylphenyl)oxane-4-carboxylic acid; 2H-Pyran-4-carboxylic acid, 4-(2-methylphenyl)tetrahydro-; 4-(2-Methylphenyl)tetrahydropyran-4-carboxylic acid; 4-o-Tolyl-tetrahydropyran-4-carboxylic acid; 3648-77-9 (CAS); 4-(2-Methylphenyl)tetrahydro-2H-pyran-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-o-Tolyl-Tetrahydro-Pyran-4-Carboxylic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.