Description

4-(4-Chlorophenyl)tetrahydro-2H-pyran-4-carbonitrile is a versatile and high-value pharmaceutical intermediate and fine chemical building block. Its unique molecular scaffold, featuring a chlorophenyl group and a nitrile-substituted tetrahydropyran ring, makes it a critical precursor in the synthesis of complex active pharmaceutical ingredients (APIs). This compound is essential for research and manufacturing organizations in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel compounds with specific biological or physical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of central nervous system (CNS) active drugs, kinase inhibitors, and other novel therapeutic agents.
• Agrochemical Synthesis: Used as a precursor in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a sophisticated chiral scaffold for creating novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials due to its rigid, functionalized structure.
• Chemical Biology Probes: Utilized in medicinal chemistry for constructing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-(4-Chlorophenyl)tetrahydro-2H-pyran-4-carbonitrile
CAS No.	3648-74-6
Molecular Formula	C12H12ClNO
Molecular Weight	221.68 g/mol
Synonyms	4-(4-Chlorophenyl)-4-cyanotetrahydropyran; 4-(p-Chlorophenyl)-4-cyanotetrahydropyran; 4-(4-Chlorophenyl)tetrahydro-4-pyrancarbonitrile; 4-(4-Chlorophenyl)-4-cyanooxane; 4-Cyano-4-(4-chlorophenyl)tetrahydropyran; 4-(4-Chlorophenyl)-4-cyanotetrahydro-2H-pyran; 4-(4-Chlorophenyl)oxane-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-(4-Chlorophenyl)tetrahydro-2H-pyran-4-carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.