Description

4-(4-Methoxy-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid is a versatile and synthetically valuable organic building block. This compound is a key chiral intermediate in the synthesis of complex molecules, prized for its rigid tetrahydropyran core and functional handles for further derivatization. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and production of novel therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its structural motif can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers or additives for advanced polymers with specific thermal or optical properties.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic synthesis, including ring-forming reactions and stereoselective transformations.

Basic Information

Product Name	4-(4-Methoxy-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid
CAS No.	3648-58-6
Molecular Formula	C13H16O4
Molecular Weight	236.26 g/mol
Synonyms	4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-(p-Methoxyphenyl)tetrahydropyran-4-carboxylic acid; 4-Carboxy-4-(4-methoxyphenyl)tetrahydropyran; 4-(4-Methoxyphenyl)oxane-4-carboxylic acid; 3648-58-6; Tetrahydropyran-4-carboxylic acid, 4-(4-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-(4-Methoxy-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for critical R&D and scale-up processes. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.