Description

1,3-Diphenyl-1,1,3,3-Tetramethyldisilazane is a versatile organosilicon compound that serves as a critical reagent and protecting group in advanced synthetic chemistry. Its primary value lies in its role as a silylating agent, effectively introducing the bulky and stable diphenyltetramethyldisilazane group to protect reactive sites like hydroxyl and amine groups. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule synthesis, including peptides and natural products.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key protecting group reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Peptide Chemistry: Employed for the selective protection of amino acids during solid-phase and solution-phase peptide synthesis to prevent unwanted side reactions.
• Agrochemical Production: Serves as a building block or intermediate in the manufacture of advanced pesticides and herbicides.
• Material Science & Polymer Chemistry: Acts as a surface modifier or a precursor in the synthesis of silicon-containing polymers and advanced materials.
• Organic Synthesis Reagent: A valuable tool for synthetic chemists for the temporary protection of sensitive functional groups, enabling challenging transformations.
• Catalyst and Ligand Preparation: Used in the preparation of specialized catalysts and ligands for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	1,3-Diphenyl-1,1,3,3-Tetramethyldisilazane
CAS No.	3449-26-1
Molecular Formula	C16H23NSi2
Molecular Weight	285.54 g/mol
Synonyms	1,3-Diphenyl-1,1,3,3-tetramethyldisilazane; Hexamethyldisilazane, 1,3-diphenyl-; N-(Diphenylsilyl)-1,1,3,3-tetramethyldisilazane; Diphenyltetramethyldisilazane; DPTMDS; HMDS, diphenyl derivative; Bis(dimethylphenylsilyl)amine; 1,1,3,3-Tetramethyl-1,3-diphenyldisilazane
EINECS	Contact for details

Quality Control

Our 1,3-Diphenyl-1,1,3,3-Tetramethyldisilazane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency suitable for research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC or HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.